Homo sapiens Protein: OSTF1
Summary
InnateDB Protein IDBP-71730.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OSTF1
Protein Name osteoclast stimulating factor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000340836
InnateDB Gene IDBG-71728 (OSTF1)
Protein Structure
UniProt Annotation
Function Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity. {ECO:0000269PubMed:10092216}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity Ubiquitously expressed. Present in osteoclasts (at protein level). {ECO:0000269PubMed:10092216}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0001503 ossification
GO:0007165 signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR002110 Ankyrin repeat
IPR011511 Variant SH3 domain
IPR020683 Ankyrin repeat-containing domain
PFAM PF00018
PF14604
PF00023
PF13606
PF07653
PF11929
PF12796
PRINTS PR00452
PR01415
PIRSF
SMART SM00326
SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92882
PhosphoSite PhosphoSite-Q92882
TrEMBL
UniProt Splice Variant
Entrez Gene 26578
UniGene Hs.494192
RefSeq NP_036515
HUGO HGNC:8510
OMIM 610180
CCDS CCDS6651
HPRD 17808
IMGT
EMBL AK222596 AL133548 BC007459 U63717
GenPept AAB06396 AAH07459 BAD96316 CAH71573