InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pou3f1

Summary

InnateDB Protein

IDBP-718061.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pou3f1

Protein Name

Synonyms

Oct-6; Oct6; Otf-6; Otf6; Scip; Test1; Tst-1; Tst1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000137374

InnateDB Gene

IDBG-486672 (Pou3f1)

Protein Structure

UniProt Annotation

Function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Thought to be involved in early embryogenesis and neurogenesis.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in embryonal stem cells and in the developing brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0008544	epidermis development
GO:0010628	positive regulation of gene expression
GO:0014044	Schwann cell development
GO:0022011	myelination in peripheral nervous system
GO:0030216	keratinocyte differentiation
GO:0030900	forebrain development
GO:0042552	myelination
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Protein Structure and Domains

PDB ID

MGI:101896

InterPro

IPR000327 POU-specific
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR010982 Lambda repressor-like, DNA-binding domain
IPR013847 POU domain
IPR016362 Transcription factor, homeobox/POU

PFAM

PF00157
PF00046
PF13413

PRINTS

PR00028

PIRSF

PIRSF002629

SMART

SM00352
SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References