InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHMP6

Summary

InnateDB Protein

IDBP-71880.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHMP6

Protein Name

charged multivesicular body protein 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000317468

InnateDB Gene

IDBG-71878 (CHMP6)

Protein Structure

UniProt Annotation

Function

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.

Subcellular Localization

Endomembrane system. Endosome membrane; Lipid-anchor. Late endosome membrane {ECO:0000305}. Note=Localizes to endosomal membranes.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:15511219}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0007034	vacuolar transport
GO:0015031	protein transport
GO:0016032	viral process
GO:0016197	endosomal transport
GO:0019058	viral life cycle
GO:0061024	membrane organization