Version 5.4
Mus musculus Protein: Dusp3
Summary
InnateDB Protein IDBP-718894.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dusp3
Protein Name
Synonyms 2210015O03Rik; 5031436O03Rik; T-DSP11; VHR;
Species Mus musculus
Ensembl Protein ENSMUSP00000135443
InnateDB Gene IDBG-212400 (Dusp3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0033549 MAP kinase phosphatase activity
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0006470 protein dephosphorylation
GO:0045931 positive regulation of mitotic cell cycle
GO:0046329 negative regulation of JNK cascade
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050868 negative regulation of T cell activation
GO:0070373 negative regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1919599
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
IPR020405 Atypical dual specificity phosphatase, subfamily A
IPR020417 Atypical dual specificity phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00782
PRINTS PR01909
PR01908
PIRSF
SMART SM00195
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL H3BKL8
UniProt Splice Variant
Entrez Gene 72349
UniGene Mm.489869
RefSeq
MGI ID
MGI Symbol Dusp3
OMIM
CCDS
HPRD
IMGT
EMBL AL591145
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca