InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC25A24

Summary

InnateDB Protein

IDBP-722156.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC25A24

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000457733

InnateDB Gene

IDBG-100654 (SLC25A24)

Protein Structure

UniProt Annotation

Function

Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress- induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix. {ECO:0000269PubMed:15123600, ECO:0000269PubMed:22015608}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000269PubMed:15054102, ECO:0000269PubMed:15123600, ECO:0000269PubMed:22015608}; Multi-pass membrane protein {ECO:0000269PubMed:15054102, ECO:0000269PubMed:15123600, ECO:0000269PubMed:22015608}.

Disease Associations

Tissue Specificity

Present in various cell lines (at protein level). Expressed in all tissues tested. Highly expressed in testis, expressed at intermediate level in small intestine and pancreas, and weakly expressed in kidney, spleen, liver, skeletal muscle and heart. {ECO:0000269PubMed:15054102, ECO:0000269PubMed:15123600}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005347	ATP transmembrane transporter activity
GO:0005509	calcium ion binding

Biological Process

GO:0006839	mitochondrial transport
GO:0010941	regulation of cell death
GO:0015867	ATP transport
GO:0034599	cellular response to oxidative stress
GO:0055085	transmembrane transport
GO:0071277	cellular response to calcium ion

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002048 EF-hand domain
IPR002067 Mitochondrial carrier protein
IPR002167 Graves disease carrier protein
IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain

PFAM

PF00036
PF13202
PF13405
PF00153

PRINTS

PR00926
PR00928

PIRSF

SMART

SM00054

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt