InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eftud1

Summary

InnateDB Protein

IDBP-722551.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eftud1

Protein Name

Synonyms

4932434J20Rik; 6030468D11Rik; AI451340; AU019507; AU022896; D7Ertd791e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000137061

InnateDB Gene

IDBG-196870 (Eftud1)

Protein Structure

UniProt Annotation

Function

Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003746	translation elongation factor activity
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0043022	ribosome binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006414	translational elongation
GO:0042256	mature ribosome assembly

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:2141969

InterPro

IPR000640 Translation elongation factor EFG, V domain
IPR000795 Elongation factor, GTP-binding domain
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR005225 Small GTP-binding protein domain
IPR009000 Translation protein, beta-barrel domain
IPR009022 Elongation factor G, III-V domain
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00679
PF00009
PF03144
PF14492

PRINTS

PR00315

PIRSF

SMART

SM00838

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt