InnateDB Protein
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IDBP-722776.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Fan1
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Protein Name
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000135335
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InnateDB Gene
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IDBG-191028 (Fan1)
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Protein Structure
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Function |
Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap- specific enzymes to unhook the ICL by cleaving the lagging-strand template (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Note=Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
14 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:3045266
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InterPro |
IPR014883
VRR-NUC domain
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PFAM |
PF08774
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PRINTS |
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PIRSF |
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SMART |
SM00990
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TIGRFAMs |
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Modification |
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SwissProt |
Q69ZT1
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PhosphoSite |
PhosphoSite-Q69ZT1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
330554
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UniGene |
Mm.236510
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RefSeq |
XP_006541022
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MGI ID |
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MGI Symbol |
Fan1
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OMIM |
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CCDS |
CCDS52265
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HPRD |
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IMGT |
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EMBL |
AC129199
AC139849
AK077918
AK173087
BC116270
BC116271
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GenPept |
AAI16271
AAI16272
BAC37062
BAD32365
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