Version 5.4
Mus musculus Protein: Flt3
Summary
InnateDB Protein IDBP-725087.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Flt3
Protein Name
Synonyms B230315G04; CD135; Flk-2; Flk2; Flt-3; Ly72; wmfl;
Species Mus musculus
Ensembl Protein ENSMUSP00000135582
InnateDB Gene IDBG-209045 (Flt3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0043548 phosphatidylinositol 3-kinase binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0002318 myeloid progenitor cell differentiation
GO:0002320 lymphoid progenitor cell differentiation
GO:0002328 pro-B cell differentiation
GO:0002572 pro-T cell differentiation
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008285 negative regulation of cell proliferation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030097 hemopoiesis
GO:0030098 lymphocyte differentiation
GO:0045578 negative regulation of B cell differentiation
GO:0046777 protein autophosphorylation
Cellular Component
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:95559
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013151 Immunoglobulin
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PF00047
PRINTS PR00109
PIRSF
SMART SM00220
SM00409
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q3TQF1
UniProt Splice Variant
Entrez Gene 14255
UniGene Mm.395216
RefSeq
MGI ID
MGI Symbol Flt3
OMIM
CCDS
HPRD
IMGT
EMBL AC127549 AC134441 AK163640
GenPept BAE37433

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca