InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPYR1

Summary

InnateDB Protein

IDBP-72578.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPYR1

Protein Name

pancreatic polypeptide receptor 1

Synonyms

NPY4-R; PP1; PPYR1; Y4;

Species

Homo sapiens

Ensembl Protein

ENSP00000363431

InnateDB Gene

IDBG-72576 (PPYR1)

Protein Structure

UniProt Annotation

Function

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highest levels found in brain, coronary artery and ileum. Low levels in pancreas and kidney. Detected in colon and small intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001601	peptide YY receptor activity
GO:0001602	pancreatic polypeptide receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0042277	peptide binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007586	digestion
GO:0007631	feeding behavior
GO:0008015	blood circulation

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR001933 Neuropeptide Y4 receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01012
PR01015

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P50391