Version 5.4
Homo sapiens Protein: NPB
Summary
InnateDB Protein IDBP-72791.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPB
Protein Name neuropeptide B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000332766
InnateDB Gene IDBG-72789 (NPB)
Protein Structure
UniProt Annotation
Function May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Widely expressed in the central nervous system. High levels are found in substantia nigra, hypothalamus, hyppocampus, spinal cord, placenta and fetal brain; lower levels are found in testis, uterus and ovary. Also detected at high levels in colorectal adenocarcinoma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR013297 Neuropeptide B/W precursor family
IPR013298 Neuropeptide B precursor
PFAM PF15180
PRINTS PR01888
PR01889
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NG41
PhosphoSite PhosphoSite-Q8NG41
TrEMBL
UniProt Splice Variant
Entrez Gene 256933
UniGene Hs.708916
RefSeq NP_683694
HUGO HGNC:30099
OMIM 607996
CCDS CCDS11790
HPRD 16267
IMGT
EMBL AB085942 AF525737 AF525738 AL360181 BC126128 BC126485 BC146875 BC146890
GenPept AAI26129 AAI26486 AAI46876 AAI46891 AAP80794 AAP80795 BAC07175

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca