InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBD

Summary

InnateDB Protein

IDBP-72961.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBD

Protein Name

ubiquitin D

Synonyms

FAT10; GABBR1; UBD-3;

Species

Homo sapiens

Ensembl Protein

ENSP00000366249

InnateDB Gene

IDBG-236915 (UBD)

Protein Structure

UniProt Annotation

Function

Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)- associated nephropathy (HIVAN). {ECO:0000269PubMed:15831455, ECO:0000269PubMed:16495226, ECO:0000269PubMed:16495380, ECO:0000269PubMed:17889673, ECO:0000269PubMed:18574467, ECO:0000269PubMed:19028597, ECO:0000269PubMed:19033385, ECO:0000269PubMed:19166848, ECO:0000269PubMed:19726511, ECO:0000269PubMed:19959714}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12730673, ECO:0000269PubMed:19033385}. Cytoplasm {ECO:0000250}. Note=Accumulates in aggresomes under proteasome inhibition conditions.

Disease Associations

Tissue Specificity

Constitutively expressed in mature dendritic cells and B-cells. Mostly expressed in the reticuloendothelial system (e.g. thymus, spleen), the gastrointestinal system, kidney, lung and prostate gland. {ECO:0000269PubMed:12730673, ECO:0000269PubMed:9368598}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 663 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	663 [view]
Protein-Protein	663 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0070628	proteasome binding

Biological Process

GO:0006508	proteolysis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0010243	response to organonitrogen compound
GO:0016567	protein ubiquitination
GO:0032446	protein modification by small protein conjugation
GO:0034341	response to interferon-gamma
GO:0034612	response to tumor necrosis factor
GO:0043011	myeloid dendritic cell differentiation
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0070842	aggresome assembly