InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BACE1

Summary

InnateDB Protein

IDBP-73183.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BACE1

Protein Name

beta-site APP-cleaving enzyme 1

Synonyms

ASP2; BACE; HSPC104;

Species

Homo sapiens

Ensembl Protein

ENSP00000318585

InnateDB Gene

IDBG-73181 (BACE1)

Protein Structure

UniProt Annotation

Function

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. {ECO:0000269PubMed:10677483, ECO:0000269PubMed:20354142}.

Subcellular Localization

Membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum. Endosome. Cell surface. Cytoplasmic vesicle membrane. Note=Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface.

Disease Associations

Tissue Specificity

Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata. {ECO:0000269PubMed:10677483, ECO:0000269PubMed:11083922}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	31 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0004175	endopeptidase activity
GO:0004190	aspartic-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008798	beta-aspartyl-peptidase activity
GO:0019899	enzyme binding

Biological Process

GO:0006508	proteolysis
GO:0006509	membrane protein ectodomain proteolysis
GO:0050435	beta-amyloid metabolic process

Cellular Component

GO:0005768	endosome
GO:0005770	late endosome
GO:0005771	multivesicular body
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030659	cytoplasmic vesicle membrane
GO:0031410	cytoplasmic vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR001461 Aspartic peptidase
IPR009119 Peptidase A1, beta-site APP cleaving enzyme, BACE
IPR009120 Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1
IPR021109 Aspartic peptidase domain

PFAM

PF00026

PRINTS

PR00792
PR01815
PR01816

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P56817