Homo sapiens Protein: DSCAML1
Summary
InnateDB Protein IDBP-73270.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DSCAML1
Protein Name Down syndrome cell adhesion molecule like 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000315465
InnateDB Gene IDBG-73268 (DSCAML1)
Protein Structure
UniProt Annotation
Function Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Detected in heart, liver, pancreas, skeletal muscle, kidney and in brain, in particular in the amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra, thalamus and subthalamus. {ECO:0000269PubMed:11453658, ECO:0000269PubMed:12051741}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001709 cell fate determination
GO:0007156 homophilic cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007409 axonogenesis
GO:0007417 central nervous system development
GO:0007420 brain development
GO:0009953 dorsal/ventral pattern formation
GO:0048704 embryonic skeletal system morphogenesis
GO:0070593 dendrite self-avoidance
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
PFAM PF00041
PF01108
PF07679
PF07686
PF00047
PRINTS
PIRSF
SMART SM00406
SM00408
SM00409
SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TD84
PhosphoSite PhosphoSite-Q8TD84
TrEMBL
UniProt Splice Variant
Entrez Gene 57453
UniGene Hs.659513
RefSeq NP_065744
HUGO HGNC:14656
OMIM 611782
CCDS CCDS8384
HPRD 10921
IMGT
EMBL AB032958 AF304304 AF304305 AF334384 AF491813 AP000711 AP000757 AP001554 AP002342
GenPept AAL57166 AAM09558 AAN32613 AAN32614 BAA86446