InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DSCAML1

Summary

InnateDB Protein

IDBP-73270.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DSCAML1

Protein Name

Down syndrome cell adhesion molecule like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000315465

InnateDB Gene

IDBG-73268 (DSCAML1)

Protein Structure

UniProt Annotation

Function

Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Detected in heart, liver, pancreas, skeletal muscle, kidney and in brain, in particular in the amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra, thalamus and subthalamus. {ECO:0000269PubMed:11453658, ECO:0000269PubMed:12051741}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001709	cell fate determination
GO:0007156	homophilic cell adhesion
GO:0007162	negative regulation of cell adhesion
GO:0007409	axonogenesis
GO:0007417	central nervous system development
GO:0007420	brain development
GO:0009953	dorsal/ventral pattern formation
GO:0048704	embryonic skeletal system morphogenesis
GO:0070593	dendrite self-avoidance

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF00041
PF01108
PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00406
SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8TD84