InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATG14

Summary

InnateDB Protein

IDBP-7340.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATG14

Protein Name

ATG14 autophagy related 14 homolog (S. cerevisiae)

Synonyms

ATG14L; BARKOR; KIAA0831;

Species

Homo sapiens

Ensembl Protein

ENSP00000247178

InnateDB Gene

IDBG-7338 (ATG14)

Protein Structure

UniProt Annotation

Function

Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. {ECO:0000269PubMed:18843052, ECO:0000269PubMed:19050071, ECO:0000269PubMed:19270696, ECO:0000269PubMed:20713597}.

Subcellular Localization

Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Cytosolic under nutrient-rich conditions. Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes. Accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0006914	autophagy
GO:0010508	positive regulation of autophagy

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005776	autophagic vacuole
GO:0005789	endoplasmic reticulum membrane
GO:0005930	axoneme
GO:0034045	pre-autophagosomal structure membrane
GO:0045335	phagocytic vesicle