Version 5.4
Homo sapiens Protein: METRNL
Summary
InnateDB Protein IDBP-73884.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol METRNL
Protein Name meteorin, glial cell differentiation regulator-like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000315731
InnateDB Gene IDBG-73882 (METRNL)
Protein Structure
UniProt Annotation
Function Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti- inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in the skeletal muscle, in subcutaneous adipose tissue, epididymal white adipose tissue depots and heart. Also expressed in brown adipose tissues and kidney. {ECO:0000269PubMed:24393292, ECO:0000269PubMed:24906147}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005179 hormone activity
Biological Process
GO:0009409 response to cold
GO:0014850 response to muscle activity
GO:0045444 fat cell differentiation
GO:0050728 negative regulation of inflammatory response
GO:0050873 brown fat cell differentiation
GO:0090336 positive regulation of brown fat cell differentiation
GO:2000507 positive regulation of energy homeostasis
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q641Q3
PhosphoSite PhosphoSite-Q641Q3
TrEMBL Q147U6
UniProt Splice Variant
Entrez Gene 284207
UniGene Hs.736335
RefSeq NP_001004431
HUGO HGNC:27584
OMIM
CCDS CCDS32779
HPRD 11255
IMGT
EMBL AC130371 AC144831 AK093748 BC050568 BC082252 BC118558 BC118638
GenPept AAH50568 AAH82252 AAI18559 AAI18639 BAG52757

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca