InnateDB Protein
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IDBP-73884.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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METRNL
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Protein Name
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meteorin, glial cell differentiation regulator-like
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000315731
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InnateDB Gene
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IDBG-73882 (METRNL)
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Protein Structure
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Function |
Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti- inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in the skeletal muscle, in subcutaneous adipose tissue, epididymal white adipose tissue depots and heart. Also expressed in brown adipose tissues and kidney. {ECO:0000269PubMed:24393292, ECO:0000269PubMed:24906147}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q641Q3
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PhosphoSite |
PhosphoSite-Q641Q3
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TrEMBL |
Q147U6
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UniProt Splice Variant |
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Entrez Gene |
284207
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UniGene |
Hs.736335
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RefSeq |
NP_001004431
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HUGO |
HGNC:27584
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OMIM |
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CCDS |
CCDS32779
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HPRD |
11255
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IMGT |
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EMBL |
AC130371
AC144831
AK093748
BC050568
BC082252
BC118558
BC118638
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GenPept |
AAH50568
AAH82252
AAI18559
AAI18639
BAG52757
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