InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IFT46

Summary

InnateDB Protein

IDBP-73979.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFT46

Protein Name

intraflagellar transport 46 homolog (Chlamydomonas)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000264020

InnateDB Gene

IDBG-73977 (IFT46)

Protein Structure

UniProt Annotation

Function

Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Note=Expression is concentrated at the cilium basal body but is also detected along the length of the cilium. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0008022	protein C-terminus binding

Biological Process

GO:0007224	smoothened signaling pathway
GO:0008150	biological_process
GO:0042073	intraciliary transport
GO:0042384	cilium assembly
GO:0050821	protein stabilization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005929	cilium
GO:0030992	intraciliary transport particle B
GO:0031512	motile primary cilium
GO:0031514	motile cilium
GO:0036064	ciliary basal body
GO:0043234	protein complex
GO:0072372	primary cilium