InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC18A3

Summary

InnateDB Protein

IDBP-74021.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC18A3

Protein Name

solute carrier family 18 (vesicular acetylcholine), member 3

Synonyms

VACHT;

Species

Homo sapiens

Ensembl Protein

ENSP00000363229

InnateDB Gene

IDBG-74019 (SLC18A3)

Protein Structure

UniProt Annotation

Function

Involved in acetylcholine transport into synaptic vesicles. {ECO:0000269PubMed:8071310}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Peripheral and central cholinergic nervous systems. {ECO:0000269PubMed:8071310}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005277	acetylcholine transmembrane transporter activity
GO:0022857	transmembrane transporter activity

Biological Process

GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0015870	acetylcholine transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0060201	clathrin-sculpted acetylcholine transport vesicle membrane

Protein Structure and Domains

PDB ID

InterPro

IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q16572

PhosphoSite