InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctnnb1

Summary

InnateDB Protein

IDBP-741737.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctnnb1

Protein Name

Synonyms

Bfc; Catnb; Mesc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000136294

InnateDB Gene

IDBG-205243 (Ctnnb1)

Protein Structure

UniProt Annotation

Function

Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (By similarity). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Cell junction, adherens junction. Cell membrane {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta- catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Colocalizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Colocalized with RAPGEF2 and TJP1 at cell-cell contacts (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 210 experimentally validated interaction(s) in this database.
They are also associated with 377 interaction(s) predicted by orthology.

Experimentally validated
Total	212 [view]
Protein-Protein	182 [view]
Protein-DNA	12 [view]
Protein-RNA	2 [view]
DNA-DNA	16 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	377 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005198	structural molecule activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0030331	estrogen receptor binding
GO:0032403	protein complex binding
GO:0035255	ionotropic glutamate receptor binding
GO:0035257	nuclear hormone receptor binding
GO:0044212	transcription regulatory region DNA binding
GO:0044325	ion channel binding
GO:0045294	alpha-catenin binding
GO:0045296	cadherin binding
GO:0070411	I-SMAD binding
GO:0070412	R-SMAD binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000578	embryonic axis specification
GO:0000904	cell morphogenesis involved in differentiation
GO:0001501	skeletal system development
GO:0001569	patterning of blood vessels
GO:0001570	vasculogenesis
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001701	in utero embryonic development
GO:0001702	gastrulation with mouth forming second
GO:0001706	endoderm formation
GO:0001708	cell fate specification
GO:0001709	cell fate determination
GO:0001711	endodermal cell fate commitment
GO:0001764	neuron migration
GO:0001822	kidney development
GO:0001840	neural plate development
GO:0001889	liver development
GO:0002052	positive regulation of neuroblast proliferation
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002089	lens morphogenesis in camera-type eye
GO:0003136	negative regulation of heart induction by canonical Wnt receptor signaling pathway
GO:0003223	ventricular compact myocardium morphogenesis
GO:0003266	regulation of secondary heart field cardioblast proliferation
GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003338	metanephros morphogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007016	cytoskeletal anchoring at plasma membrane
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007268	synaptic transmission
GO:0007398	ectoderm development
GO:0007403	glial cell fate determination
GO:0007494	midgut development
GO:0007507	heart development
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009948	anterior/posterior axis specification
GO:0009950	dorsal/ventral axis specification
GO:0009953	dorsal/ventral pattern formation
GO:0009954	proximal/distal pattern formation
GO:0009987	cellular process
GO:0010468	regulation of gene expression
GO:0010628	positive regulation of gene expression
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0014010	Schwann cell proliferation
GO:0016055	Wnt signaling pathway
GO:0016331	morphogenesis of embryonic epithelium
GO:0016337	single organismal cell-cell adhesion
GO:0021819	layer formation in cerebral cortex
GO:0022009	central nervous system vasculogenesis
GO:0022405	hair cycle process
GO:0030097	hemopoiesis
GO:0030154	cell differentiation
GO:0030217	T cell differentiation
GO:0030316	osteoclast differentiation
GO:0030324	lung development
GO:0030539	male genitalia development
GO:0030856	regulation of epithelial cell differentiation
GO:0030858	positive regulation of epithelial cell differentiation
GO:0030900	forebrain development
GO:0030902	hindbrain development
GO:0030997	regulation of centriole-centriole cohesion
GO:0031016	pancreas development
GO:0031069	hair follicle morphogenesis
GO:0031641	regulation of myelination
GO:0032331	negative regulation of chondrocyte differentiation
GO:0032355	response to estradiol
GO:0033077	T cell differentiation in thymus
GO:0033234	negative regulation of protein sumoylation
GO:0034097	response to cytokine
GO:0034333	adherens junction assembly
GO:0034394	protein localization to cell surface
GO:0034613	cellular protein localization
GO:0035050	embryonic heart tube development
GO:0035112	genitalia morphogenesis
GO:0035115	embryonic forelimb morphogenesis
GO:0035116	embryonic hindlimb morphogenesis
GO:0036023	embryonic skeletal limb joint morphogenesis
GO:0042127	regulation of cell proliferation
GO:0042129	regulation of T cell proliferation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042493	response to drug
GO:0042733	embryonic digit morphogenesis
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410	positive regulation of MAPK cascade
GO:0043588	skin development
GO:0043627	response to estrogen
GO:0044334	canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0045445	myoblast differentiation
GO:0045453	bone resorption
GO:0045595	regulation of cell differentiation
GO:0045596	negative regulation of cell differentiation
GO:0045603	positive regulation of endothelial cell differentiation
GO:0045667	regulation of osteoblast differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045670	regulation of osteoclast differentiation
GO:0045671	negative regulation of osteoclast differentiation
GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046686	response to cadmium ion
GO:0048469	cell maturation
GO:0048489	synaptic vesicle transport
GO:0048513	organ development
GO:0048538	thymus development
GO:0048599	oocyte development
GO:0048617	embryonic foregut morphogenesis
GO:0048660	regulation of smooth muscle cell proliferation
GO:0048715	negative regulation of oligodendrocyte differentiation
GO:0050808	synapse organization
GO:0051145	smooth muscle cell differentiation
GO:0051291	protein heterooligomerization
GO:0060038	cardiac muscle cell proliferation
GO:0060066	oviduct development
GO:0060070	canonical Wnt signaling pathway
GO:0060173	limb development
GO:0060439	trachea morphogenesis
GO:0060440	trachea formation
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0060479	lung cell differentiation
GO:0060484	lung-associated mesenchyme development
GO:0060485	mesenchyme development
GO:0060492	lung induction
GO:0060742	epithelial cell differentiation involved in prostate gland development
GO:0060769	positive regulation of epithelial cell proliferation involved in prostate gland development
GO:0060789	hair follicle placode formation
GO:0060916	mesenchymal cell proliferation involved in lung development
GO:0060947	cardiac vascular smooth muscle cell differentiation
GO:0060982	coronary artery morphogenesis
GO:0060983	epicardium-derived cardiac vascular smooth muscle cell differentiation
GO:0061047	positive regulation of branching involved in lung morphogenesis
GO:0061154	endothelial tube morphogenesis
GO:0061198	fungiform papilla formation
GO:0061324	canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:0070602	regulation of centromeric sister chromatid cohesion
GO:0071260	cellular response to mechanical stimulus
GO:0071363	cellular response to growth factor stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071681	cellular response to indole-3-methanol
GO:0072001	renal system development
GO:0072033	renal vesicle formation
GO:0072053	renal inner medulla development
GO:0072054	renal outer medulla development
GO:0072079	nephron tubule formation
GO:0072132	mesenchyme morphogenesis
GO:0072182	regulation of nephron tubule epithelial cell differentiation
GO:0090279	regulation of calcium ion import
GO:1901215	negative regulation of neuron death
GO:2000008	regulation of protein localization to cell surface
GO:2000017	positive regulation of determination of dorsal identity
GO:2001234	negative regulation of apoptotic signaling pathway

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0005913	cell-cell adherens junction
GO:0005915	zonula adherens
GO:0005916	fascia adherens
GO:0005923	tight junction
GO:0005938	cell cortex
GO:0009898	cytoplasmic side of plasma membrane
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016328	lateral plasma membrane
GO:0016342	catenin complex
GO:0030018	Z disc
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0030057	desmosome
GO:0030877	beta-catenin destruction complex
GO:0031253	cell projection membrane
GO:0031528	microvillus membrane
GO:0032993	protein-DNA complex
GO:0034750	Scrib-APC-beta-catenin complex
GO:0043198	dendritic shaft
GO:0043296	apical junction complex
GO:0045177	apical part of cell
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm
GO:0070369	beta-catenin-TCF7L2 complex
GO:0071664	catenin-TCF7L2 complex
GO:0071944	cell periphery