InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARR3

Summary

InnateDB Protein

IDBP-74324.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARR3

Protein Name

arrestin 3, retinal (X-arrestin)

Synonyms

ARRX;

Species

Homo sapiens

Ensembl Protein

ENSP00000311538

InnateDB Gene

IDBG-74318 (ARR3)

Protein Structure

UniProt Annotation

Function

May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.

Subcellular Localization

Disease Associations

Tissue Specificity

Inner and outer segments, and the inner plexiform regions of the retina.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002046	opsin binding
GO:0005515	protein binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0006897	endocytosis
GO:0007165	signal transduction
GO:0007601	visual perception

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005737	cytoplasm
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR000698 Arrestin
IPR011021 Arrestin-like, N-terminal
IPR011022 Arrestin C-terminal-like domain
IPR014756 Immunoglobulin E-set

PFAM

PF00339
PF02752

PRINTS

PR00309

PIRSF

SMART

SM01017

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P36575

PhosphoSite

PhosphoSite-

TrEMBL

D6RCT3

UniProt Splice Variant

Entrez Gene

407

UniGene

Hs.308

RefSeq

NP_004303

HUGO

HGNC:710

OMIM

301770

CCDS

CCDS14399

HPRD

02358

IMGT

EMBL

AF033105 AF076497 AF076498 AF076499 AF076500 AF076501 AF076502 AF076503 AF076504 AF076505 AF076506 AF076507 AF076508 AF076509 AF076510 AF076511 AF076512 AL357752 BC012096 CR456849 EU883571 U03626

GenPept

AAB84302 AAC27524 AAC78395 AAH12096 ACG60645 CAG33130 CAI41490 CAI41491