Version 5.4
Homo sapiens Protein: ISCA1
Summary
InnateDB Protein IDBP-74679.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ISCA1
Protein Name iron-sulfur cluster assembly 1 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000365159
InnateDB Gene IDBG-74675 (ISCA1)
Protein Structure
UniProt Annotation
Function Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. {ECO:0000269PubMed:15262227, ECO:0000269PubMed:22323289}.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:15262227, ECO:0000269PubMed:22323289}.
Disease Associations
Tissue Specificity Detected in cerebellum, kidney and heart. {ECO:0000269PubMed:15262227}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0016226 iron-sulfur cluster assembly
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR000361 FeS cluster biogenesis
IPR016092 FeS cluster insertion protein
PFAM PF01521
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BUE6
PhosphoSite PhosphoSite-
TrEMBL Q5TBE2
UniProt Splice Variant
Entrez Gene 81689
UniGene Hs.449291
RefSeq NP_112202
HUGO HGNC:28660
OMIM 611006
CCDS CCDS35056
HPRD 17091
IMGT
EMBL AF284752 AK055643 AK296093 AL137849 AL834356 AY015642 BC002675 BC071621 CH471089
GenPept AAG40950 AAG59854 AAH02675 AAH71621 BAG51546 BAG58847 CAD39021 CAI14925 EAW62713

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca