Version 5.4
Homo sapiens Protein: FBXO22
Summary
InnateDB Protein IDBP-746809.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO22
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000457531
InnateDB Gene IDBG-23786 (FBXO22)
Protein Structure
UniProt Annotation
Function Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. {ECO:0000269PubMed:22972877}.
Subcellular Localization Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}.
Disease Associations
Tissue Specificity Predominantly expressed in liver, also enriched in cardiac muscle. {ECO:0000269PubMed:22972877}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0006511 ubiquitin-dependent protein catabolic process
Cellular Component
GO:0030018 Z disc
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NEZ5
PhosphoSite PhosphoSite-Q8NEZ5
TrEMBL
UniProt Splice Variant
Entrez Gene 26263
UniGene Hs.601357
RefSeq
HUGO HGNC:13593
OMIM 609096
CCDS
HPRD 16437
IMGT
EMBL AC027104 AF174602 AK024048 AY005144 BC020204 BC032540 BC039024 BC041691
GenPept AAF04523 AAF89095 AAH20204 AAH32540 AAH39024 AAH41691 BAB14798

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca