InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LBP

Summary

InnateDB Protein

IDBP-74723.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LBP

Protein Name

lipopolysaccharide binding protein

Synonyms

BPIFD2;

Species

Homo sapiens

Ensembl Protein

ENSP00000217407

InnateDB Gene

IDBG-74721 (LBP)

Protein Structure

UniProt Annotation

Function

Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide. {ECO:0000269PubMed:17481951, ECO:0000269PubMed:24120359}.

Subcellular Localization

Secreted {ECO:0000269PubMed:24120359}.

Disease Associations

Tissue Specificity

Detected in blood serum (at protein level). {ECO:0000269PubMed:24120359}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	21 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0070891	lipoteichoic acid binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002232	leukocyte chemotaxis involved in inflammatory response
GO:0002281	macrophage activation involved in immune response
GO:0006953	acute-phase response
GO:0006968	cellular defense response
GO:0008228	opsonization
GO:0015920	lipopolysaccharide transport
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032490	detection of molecule of bacterial origin
GO:0032496	response to lipopolysaccharide
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032722	positive regulation of chemokine production
GO:0032755	positive regulation of interleukin-6 production
GO:0032757	positive regulation of interleukin-8 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034145	positive regulation of toll-like receptor 4 signaling pathway
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
GO:0043032	positive regulation of macrophage activation
GO:0044130	negative regulation of growth of symbiont in host
GO:0045087	innate immune response
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium
GO:0060265	positive regulation of respiratory burst involved in inflammatory response
GO:0071222	cellular response to lipopolysaccharide
GO:0071223	cellular response to lipoteichoic acid
GO:0090023	positive regulation of neutrophil chemotaxis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0009986	cell surface
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001124 Lipid-binding serum glycoprotein, C-terminal
IPR017942 Lipid-binding serum glycoprotein, N-terminal
IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain

PFAM

PF02886
PF01273

PRINTS

PIRSF

SMART

SM00329
SM00328

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P18428