Version 5.4
Homo sapiens Protein: HCFC1R1
Summary
InnateDB Protein IDBP-748456.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HCFC1R1
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000460639
InnateDB Gene IDBG-11366 (HCFC1R1)
Protein Structure
UniProt Annotation
Function Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus. {ECO:0000269PubMed:12235138}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12235138}. Nucleus {ECO:0000269PubMed:12235138}. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:12235138}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NWW0
PhosphoSite PhosphoSite-Q9NWW0
TrEMBL I3L1N5
UniProt Splice Variant
Entrez Gene 54985
UniGene
RefSeq NP_001275597
HUGO HGNC:21198
OMIM
CCDS CCDS10490
HPRD 13636
IMGT
EMBL AC108134 AK000575 AY116892 BC064026 BC080178 CH471112 CR457245
GenPept AAH64026 AAH80178 AAM49798 BAA91265 CAG33526 EAW85425 EAW85426

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca