InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: THOC6

Summary

InnateDB Protein

IDBP-748865.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

THOC6

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000460015

InnateDB Gene

IDBG-11385 (THOC6)

Protein Structure

UniProt Annotation

Function

Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development. {ECO:0000269PubMed:15833825, ECO:0000269PubMed:15998806, ECO:0000269PubMed:17190602, ECO:0000269PubMed:18974867, ECO:0000269PubMed:23621916}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:23621916}. Nucleus speckle {ECO:0000305PubMed:23621916}.

Disease Associations

Beaulieu-Boycott-Innes syndrome (BBIS) [MIM:613680]: An autosomal recessive neurodevelopmental disorder characterized by delayed development, moderate intellectual disability, and dysmorphic facial features. Other developmental anomalies, such as cardiac and renal defects, may also occur. {ECO:0000269PubMed:23621916}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	45 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding

Biological Process

GO:0006397	mRNA processing
GO:0006406	mRNA export from nucleus
GO:0006915	apoptotic process
GO:0007417	central nervous system development
GO:0008380	RNA splicing
GO:0043066	negative regulation of apoptotic process
GO:0046784	intronless viral mRNA export from host nucleus

Cellular Component

GO:0000346	transcription export complex
GO:0000347	THO complex
GO:0000445	THO complex part of transcription export complex
GO:0005634	nucleus
GO:0016607	nuclear speck