InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TBL1Y

Summary

InnateDB Protein

IDBP-75.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TBL1Y

Protein Name

transducin (beta)-like 1, Y-linked

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000328879

InnateDB Gene

IDBG-67 (TBL1Y)

Protein Structure

UniProt Annotation

Function

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Fetal brain and prostate. {ECO:0000269PubMed:12815422}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006351

transcription, DNA-templated

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR006594 LisH dimerisation motif
IPR013720 LisH dimerisation motif, subgroup
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat

PFAM

PF00400
PF08513

PRINTS

PR00320

PIRSF

SMART

SM00320
SM00667

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt