InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HP

Summary

InnateDB Protein

IDBP-750632.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

Synonyms

BP; HP2ALPHA2; HPA1S;

Species

Homo sapiens

Ensembl Protein

ENSP00000454966

InnateDB Gene

IDBG-547150 (HP)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0016209	antioxidant activity
GO:0030492	hemoglobin binding

Biological Process

GO:0002376	immune system process
GO:0006508	proteolysis
GO:0006952	defense response
GO:0006953	acute-phase response
GO:0008152	metabolic process
GO:0010942	positive regulation of cell death
GO:0042542	response to hydrogen peroxide
GO:0042742	defense response to bacterium
GO:0051354	negative regulation of oxidoreductase activity
GO:2000296	negative regulation of hydrogen peroxide catabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0031838	haptoglobin-hemoglobin complex
GO:0070062	extracellular vesicular exosome
GO:0071682	endocytic vesicle lumen
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

InterPro

IPR000436 Sushi/SCR/CCP
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR008292 Haptoglobin
IPR009003 Trypsin-like cysteine/serine peptidase domain

PFAM

PF00084
PF00089

PRINTS

PR00722

PIRSF

PIRSF001137

SMART

SM00032
SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References