InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CARHSP1

Summary

InnateDB Protein

IDBP-752526.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CARHSP1

Protein Name

Synonyms

CRHSP-24; CSDC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000455855

InnateDB Gene

IDBG-13931 (CARHSP1)

Protein Structure

UniProt Annotation

Function

Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro). {ECO:0000269PubMed:21078874, ECO:0000269PubMed:21177848}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21177848}. Cytoplasm, P-body {ECO:0000269PubMed:21177848}. Cytoplasmic granule {ECO:0000269PubMed:21177848}. Note=Detected at cytoplasmic stress granules and P-bodies. Detected at exosome granules where mRNA is degraded (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0019902	phosphatase binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0035556	intracellular signal transduction
GO:0043488	regulation of mRNA stability

Cellular Component

GO:0000177	cytoplasmic exosome (RNase complex)
GO:0000932	cytoplasmic mRNA processing body
GO:0005829	cytosol
GO:0043186	P granule
GO:0070062	extracellular vesicular exosome