InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HOXD10

Summary

InnateDB Protein

IDBP-75706.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOXD10

Protein Name

homeobox D10

Synonyms

Hox-4.4; HOX4; HOX4D; HOX4E;

Species

Homo sapiens

Ensembl Protein

ENSP00000249501

InnateDB Gene

IDBG-75704 (HOXD10)

Protein Structure

UniProt Annotation

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular Localization

Nucleus.

Disease Associations

Vertical talus, congenital (CVT) [MIM:192950]: A rare malformation characterized by vertical orientation of the talus with a rigid dorsal dislocation of the navicular, equinus deformity of the calcaneus, abduction deformity of the forefoot, and contracture of the soft tissues of the hind- and mid-foot. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity with familial occurrence. {ECO:0000269PubMed:15146389}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Strongly expressed in the adult male and female urogenital tracts.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001501	skeletal system development
GO:0006351	transcription, DNA-templated
GO:0007338	single fertilization
GO:0007519	skeletal muscle tissue development
GO:0008344	adult locomotory behavior
GO:0009952	anterior/posterior pattern specification
GO:0009954	proximal/distal pattern formation
GO:0010468	regulation of gene expression
GO:0021520	spinal cord motor neuron cell fate specification
GO:0030326	embryonic limb morphogenesis
GO:0035136	forelimb morphogenesis
GO:0035137	hindlimb morphogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048704	embryonic skeletal system morphogenesis
GO:0048935	peripheral nervous system neuron development
GO:0050905	neuromuscular process