InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HOXD9

Summary

InnateDB Protein

IDBP-75721.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOXD9

Protein Name

homeobox D9

Synonyms

Hox-4.3; Hox-5.2; HOX4; HOX4C;

Species

Homo sapiens

Ensembl Protein

ENSP00000249499

InnateDB Gene

IDBG-75719 (HOXD9)

Protein Structure

UniProt Annotation

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007338	single fertilization
GO:0007519	skeletal muscle tissue development
GO:0008344	adult locomotory behavior
GO:0009952	anterior/posterior pattern specification
GO:0009954	proximal/distal pattern formation
GO:0010468	regulation of gene expression
GO:0030879	mammary gland development
GO:0035115	embryonic forelimb morphogenesis
GO:0035136	forelimb morphogenesis
GO:0035137	hindlimb morphogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048704	embryonic skeletal system morphogenesis
GO:0048706	embryonic skeletal system development
GO:0048935	peripheral nervous system neuron development

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001356 Homeobox domain
IPR006711 Hox9, N-terminal activation domain
IPR009057 Homeodomain-like
IPR017112 Homeobox protein Hox9
IPR020479 Homeodomain, metazoa

PFAM

PF00046
PF04617

PRINTS

PR00024

PIRSF

PIRSF037109

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References