InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: L3MBTL1

Summary

InnateDB Protein

IDBP-75818.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

L3MBTL1

Protein Name

l(3)mbt-like 1 (Drosophila)

Synonyms

dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3;

Species

Homo sapiens

Ensembl Protein

ENSP00000362227

InnateDB Gene

IDBG-75814 (L3MBTL1)

Protein Structure

UniProt Annotation

Function

Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post- translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. {ECO:0000269PubMed:17540172, ECO:0000269PubMed:18408754, ECO:0000269PubMed:20870719, ECO:0000269PubMed:20870725}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10445843}. Note=Excluded from the nucleolus. Does not colocalizes with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex.

Disease Associations

Tissue Specificity

Widely expressed. Expression is reduced in colorectal cancer cell line SW480 and promyelocytic leukemia cell line HL-60. {ECO:0000269PubMed:10445843}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	32 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031491	nucleosome binding
GO:0031493	nucleosomal histone binding
GO:0032093	SAM domain binding
GO:0035064	methylated histone binding
GO:0042393	histone binding
GO:0042802	identical protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007088	regulation of mitosis
GO:0016568	chromatin modification
GO:0030097	hemopoiesis
GO:0045652	regulation of megakaryocyte differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051726	regulation of cell cycle