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InnateDB Protein
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IDBP-75820.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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L3MBTL1
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Protein Name
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l(3)mbt-like 1 (Drosophila)
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Synonyms
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dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000362226
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InnateDB Gene
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IDBG-75814 (L3MBTL1)
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Protein Structure
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| Function |
Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post- translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. {ECO:0000269PubMed:17540172, ECO:0000269PubMed:18408754, ECO:0000269PubMed:20870719, ECO:0000269PubMed:20870725}.
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| Subcellular Localization |
Nucleus {ECO:0000269PubMed:10445843}. Note=Excluded from the nucleolus. Does not colocalizes with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex.
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| Disease Associations |
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| Tissue Specificity |
Widely expressed. Expression is reduced in colorectal cancer cell line SW480 and promyelocytic leukemia cell line HL-60. {ECO:0000269PubMed:10445843}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
37
[view]
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| Protein-Protein |
32
[view]
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| Protein-DNA |
5
[view]
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
2 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0008270
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zinc ion binding
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| Biological Process |
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GO:0006355
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regulation of transcription, DNA-templated
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR002515
Zinc finger, C2HC-type
IPR004092
Mbt repeat
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| PFAM |
PF01530
PF02820
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| PRINTS |
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| PIRSF |
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| SMART |
SM00561
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q9Y468
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| TrEMBL |
B0QYN5
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| UniProt Splice Variant |
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| Entrez Gene |
26013
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| UniGene |
Hs.709356
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| RefSeq |
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| HUGO |
HGNC:15905
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| OMIM |
608802
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| CCDS |
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| HPRD |
16387
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| IMGT |
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| EMBL |
AL031681
Z98752
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| GenPept |
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Version 5.4