InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AGPS

Summary

InnateDB Protein

IDBP-75884.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGPS

Protein Name

alkylglycerone phosphate synthase

Synonyms

ADAP-S; ADAS; ADHAPS; ADPS; ALDHPSY;

Species

Homo sapiens

Ensembl Protein

ENSP00000264167

InnateDB Gene

IDBG-75882 (AGPS)

Protein Structure

UniProt Annotation

Function

Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids. {ECO:0000250}.

Subcellular Localization

Peroxisome membrane. Note=Localized to the inner aspect of the peroxisomal membrane.

Disease Associations

Rhizomelic chondrodysplasia punctata 3 (RCDP3) [MIM:600121]: A disease characterized by rhizomelic shortening of femur and humerus, vertebral disorders, cataract, cutaneous lesions and severe mental retardation. {ECO:0000269PubMed:11152660, ECO:0000269PubMed:21990100, ECO:0000269PubMed:9553082}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	19 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0008609	alkylglycerone-phosphate synthase activity
GO:0008762	UDP-N-acetylmuramate dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors
GO:0050660	flavin adenine dinucleotide binding
GO:0071949	FAD binding

Biological Process

GO:0008610	lipid biosynthetic process
GO:0008611	ether lipid biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005730	nucleolus
GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005782	peroxisomal matrix
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR004113 FAD-linked oxidase, C-terminal
IPR006094 FAD linked oxidase, N-terminal
IPR016164 FAD-linked oxidase-like, C-terminal
IPR016166 FAD-binding, type 2

PFAM

PF02913
PF01565

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O00116

PhosphoSite