InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GJD3

Summary

InnateDB Protein

IDBP-759168.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GJD3

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000463752

InnateDB Gene

IDBG-47529 (GJD3)

Protein Structure

UniProt Annotation

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12154091}; Multi-pass membrane protein {ECO:0000269PubMed:12154091}. Cell junction, gap junction {ECO:0000269PubMed:12154091}.

Disease Associations

Tissue Specificity

Expressed in vascular smooth muscle cells. Found in heart, colon, and artery (at protein level). Found in cerebral cortex, heart, liver, lung, kidney, spleen and testis. {ECO:0000269PubMed:12154091, ECO:0000269PubMed:12176752}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005243	gap junction channel activity
GO:0005515	protein binding

Biological Process

GO:0007154	cell communication
GO:0009749	response to glucose
GO:0016264	gap junction assembly
GO:0034220	ion transmembrane transport
GO:0055085	transmembrane transport