InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF4A1

Summary

InnateDB Protein

IDBP-759235.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF4A1

Protein Name

Synonyms

DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I;

Species

Homo sapiens

Ensembl Protein

ENSP00000463486

InnateDB Gene

IDBG-25777 (EIF4A1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	100 [view]
Protein-Protein	99 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000339	RNA cap binding
GO:0003676	nucleic acid binding
GO:0003725	double-stranded RNA binding
GO:0003729	mRNA binding
GO:0003743	translation initiation factor activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0008135	translation factor activity, nucleic acid binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006200	ATP catabolic process
GO:0006412	translation
GO:0006413	translational initiation
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019221	cytokine-mediated signaling pathway
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane
GO:0016281	eukaryotic translation initiation factor 4F complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P60842