Version 5.4
Homo sapiens Protein: GJC1
Summary
InnateDB Protein IDBP-759564.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GJC1
Protein Name
Synonyms CX45; GJA7;
Species Homo sapiens
Ensembl Protein ENSP00000467201
InnateDB Gene IDBG-54323 (GJC1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006810 transport
GO:0006936 muscle contraction
GO:0007043 cell-cell junction assembly
GO:0007268 synaptic transmission
GO:0016264 gap junction assembly
GO:0061024 membrane organization
GO:0086014 atrial cardiac muscle cell action potential
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005921 gap junction
GO:0014704 intercalated disc
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000500 Connexin
IPR002265 Gap junction alpha-6 protein (Cx45)
IPR013092 Connexin, N-terminal
IPR019570 Gap junction protein, cysteine-rich domain
PFAM PF00029
PF10582
PRINTS PR00206
PR01136
PIRSF
SMART SM00037
SM01089
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P36383
PhosphoSite PhosphoSite-P36383
TrEMBL Q5H9P2
UniProt Splice Variant
Entrez Gene 10052
UniGene Hs.740882
RefSeq NP_005488
HUGO HGNC:4280
OMIM 608655
CCDS CCDS11487
HPRD 08819
IMGT
EMBL AC005180 AK124339 BC096213 BC096214 BC096215 BC096216 CR933719 U03493
GenPept AAA60458 AAH96213 AAH96214 AAH96215 AAH96216 BAG54030 CAI46249

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca