InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNF43

Summary

InnateDB Protein

IDBP-759622.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF43

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000463069

InnateDB Gene

IDBG-61124 (RNF43)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. {ECO:0000269PubMed:18313049, ECO:0000269PubMed:22575959, ECO:0000269PubMed:22895187}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope. Note=According to a report, may be secreted. {ECO:0000269PubMed:15492824}.

Disease Associations

Tissue Specificity

Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines. {ECO:0000269PubMed:15492824, ECO:0000269PubMed:18313049}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0016055	Wnt signaling pathway
GO:0016567	protein ubiquitination
GO:0030178	negative regulation of Wnt signaling pathway
GO:0038018	Wnt receptor catabolic process
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0072089	stem cell proliferation