Version 5.4
Homo sapiens Protein: DNAH2
Summary
InnateDB Protein IDBP-759681.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNAH2
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000460245
InnateDB Gene IDBG-26706 (DNAH2)
Protein Structure
UniProt Annotation
Function Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung. {ECO:0000269PubMed:9256245}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0016887 ATPase activity
Biological Process
GO:0001539 cilium or flagellum-dependent cell motility
GO:0006200 ATP catabolic process
GO:0007018 microtubule-based movement
GO:0008152 metabolic process
Cellular Component
GO:0005858 axonemal dynein complex
GO:0005874 microtubule
Protein Structure and Domains
PDB ID
InterPro IPR013594 Dynein heavy chain, domain-1
PFAM PF08385
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P225
PhosphoSite PhosphoSite-Q9P225
TrEMBL
UniProt Splice Variant
Entrez Gene 146754
UniGene Hs.367649
RefSeq
HUGO HGNC:2948
OMIM 603333
CCDS
HPRD 17214
IMGT
EMBL AB040936 AC025335 AC087388 AK128517 AK292607 BC034225 U83570
GenPept AAB82760 AAH34225 BAA96027 BAF85296

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca