Version 5.4
Homo sapiens Protein: RNF43
Summary
InnateDB Protein IDBP-759706.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF43
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000463716
InnateDB Gene IDBG-61124 (RNF43)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. {ECO:0000269PubMed:18313049, ECO:0000269PubMed:22575959, ECO:0000269PubMed:22895187}.
Subcellular Localization Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope. Note=According to a report, may be secreted. {ECO:0000269PubMed:15492824}.
Disease Associations
Tissue Specificity Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines. {ECO:0000269PubMed:15492824, ECO:0000269PubMed:18313049}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005109 frizzled binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0016055 Wnt signaling pathway
GO:0016567 protein ubiquitination
GO:0030178 negative regulation of Wnt signaling pathway
GO:0038018 Wnt receptor catabolic process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0072089 stem cell proliferation
Cellular Component
GO:0005635 nuclear envelope
GO:0005789 endoplasmic reticulum membrane
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q68DV7
PhosphoSite PhosphoSite-Q68DV7
TrEMBL
UniProt Splice Variant
Entrez Gene 54894
UniGene Hs.688837
RefSeq
HUGO HGNC:18505
OMIM 612482
CCDS
HPRD 07896
IMGT
EMBL AB081837 AK000322 AK291027 AK296769 AK298789 AK299024 BC109028 CR627423 CR749257
GenPept AAI09029 BAA91085 BAD51435 BAF83716 BAH12429 BAH12871 BAH12931 CAH10510 CAH18113

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca