InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTDNEP1

Summary

InnateDB Protein

IDBP-760874.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTDNEP1

Protein Name

Synonyms

DULLARD; HSA011916; NET56;

Species

Homo sapiens

Ensembl Protein

ENSP00000461749

InnateDB Gene

IDBG-23930 (CTDNEP1)

Protein Structure

UniProt Annotation

Function

Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling. {ECO:0000269PubMed:17420445, ECO:0000269PubMed:22134922}.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Muscle specific with lower expression in other metabolic tissues. {ECO:0000269PubMed:22134922}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0006998	nuclear envelope organization
GO:0007276	gamete generation
GO:0007498	mesoderm development
GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0016311	dephosphorylation
GO:0034504	protein localization to nucleus
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane
GO:0071595	Nem1-Spo7 phosphatase complex