InnateDB Protein
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IDBP-761163.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PLXDC1
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Protein Name
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000462089
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InnateDB Gene
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IDBG-45218 (PLXDC1)
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Protein Structure
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Function |
Plays a critical role in endothelial cell capillary morphogenesis. {ECO:0000250}.
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Subcellular Localization |
Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.Isoform 2: Secreted {ECO:0000305}.Isoform 3: Secreted {ECO:0000305}.Isoform 4: Cytoplasm {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy. {ECO:0000269PubMed:10947988, ECO:0000269PubMed:11559528, ECO:0000269PubMed:17560052, ECO:0000269PubMed:18316703}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR016201
Plexin-like fold
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
SM00423
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IUK5
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PhosphoSite |
PhosphoSite-Q8IUK5
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TrEMBL |
J3QR40
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UniProt Splice Variant |
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Entrez Gene |
57125
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UniGene |
Hs.739581
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RefSeq |
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HUGO |
HGNC:20945
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OMIM |
606826
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CCDS |
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HPRD |
08439
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IMGT |
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EMBL |
AC004408
AC091178
AF279144
AF378753
AK312999
AY704670
AY704671
AY704672
BC036059
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GenPept |
AAG00869
AAH36059
AAL11990
AAV85657
AAV85658
AAV85659
BAG35835
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