Version 5.4
Homo sapiens Protein: TEFM
Summary
InnateDB Protein IDBP-762049.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TEFM
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000462963
InnateDB Gene IDBG-39317 (TEFM)
Protein Structure
UniProt Annotation
Function Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery. {ECO:0000269PubMed:21278163}.
Subcellular Localization Mitochondrion matrix {ECO:0000269PubMed:21278163}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269PubMed:21278163}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0030337 DNA polymerase processivity factor activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006119 oxidative phosphorylation
GO:0006259 DNA metabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006390 transcription from mitochondrial promoter
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0030529 ribonucleoprotein complex
GO:0042645 mitochondrial nucleoid
Protein Structure and Domains
PDB ID
InterPro IPR012337 Ribonuclease H-like domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96QE5
PhosphoSite PhosphoSite-Q96QE5
TrEMBL
UniProt Splice Variant
Entrez Gene 79736
UniGene Hs.317340
RefSeq NP_078959
HUGO HGNC:26223
OMIM
CCDS CCDS42291
HPRD 08005
IMGT
EMBL AJ314645 AK026382 BC009025 BC073169 CH471147 CR457360
GenPept AAH09025 AAH73169 BAB15468 CAC44534 CAG33641 EAW80290 EAW80292

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca