InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP1R10

Summary

InnateDB Protein

IDBP-76376.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP1R10

Protein Name

protein phosphatase 1, regulatory subunit 10

Synonyms

CAT53; FB19; p99; PNUTS; PP1R10; R111;

Species

Homo sapiens

Ensembl Protein

ENSP00000365694

InnateDB Gene

IDBG-76372 (PPP1R10)

Protein Structure

UniProt Annotation

Function

Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00649, ECO:0000269PubMed:9450550}. Note=Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:9450550, ECO:0000269PubMed:9784381}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004864	protein phosphatase inhibitor activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006606	protein import into nucleus
GO:0043086	negative regulation of catalytic activity

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0072357	PTW/PP1 phosphatase complex

Protein Structure and Domains

PDB ID

InterPro

IPR000571 Zinc finger, CCCH-type
IPR003617 Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type
IPR017923 Transcription factor IIS, N-terminal

PFAM

PF00642
PF08711

PRINTS

PIRSF

SMART

SM00356
SM00509

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96QC0