InnateDB Protein
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IDBP-76475.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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C9orf89
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Protein Name
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chromosome 9 open reading frame 89
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000364613
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InnateDB Gene
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IDBG-76473 (C9orf89)
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Protein Structure
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Function |
Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner. {ECO:0000269PubMed:15637807}.
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Subcellular Localization |
Isoform 1: Nucleus {ECO:0000269PubMed:23633586}. Note=Coexpression with BCL10 induced translocation from nucleus to cytosol.Isoform 2: Endoplasmic reticulum membrane {ECO:0000269PubMed:23633586}; Single-pass membrane protein {ECO:0000269PubMed:23633586}. Mitochondrion membrane {ECO:0000269PubMed:23633586}; Single-pass membrane protein {ECO:0000269PubMed:23633586}.
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Disease Associations |
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Tissue Specificity |
Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain. {ECO:0000269PubMed:15637807}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0043124
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negative regulation of I-kappaB kinase/NF-kappaB signaling
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Cellular Component |
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PDB ID |
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InterPro |
IPR011029
Death-like domain
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96LW7
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PhosphoSite |
PhosphoSite-Q96LW7
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TrEMBL |
A0A024R248
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UniProt Splice Variant |
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Entrez Gene |
84270
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UniGene |
Hs.434213
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RefSeq |
NP_115686
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HUGO |
HGNC:28148
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OMIM |
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CCDS |
CCDS6702
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HPRD |
12985
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IMGT |
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EMBL |
AK057716
AL451065
BC004500
BC038856
CH471089
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GenPept |
AAH04500
AAH38856
BAB71550
CAI95110
EAW62851
EAW62852
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