Version 5.4
Homo sapiens Protein: TMC8
Summary
InnateDB Protein IDBP-764791.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMC8
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000467482
InnateDB Gene IDBG-70424 (TMC8)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0001558 regulation of cell growth
GO:0006811 ion transport
GO:0032091 negative regulation of protein binding
GO:0032460 negative regulation of protein oligomerization
GO:0055069 zinc ion homeostasis
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR012496 TMC
PFAM PF07810
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IU68
PhosphoSite PhosphoSite-Q8IU68
TrEMBL B3KXZ8
UniProt Splice Variant
Entrez Gene 147138
UniGene Hs.592102
RefSeq
HUGO HGNC:20474
OMIM 605829
CCDS
HPRD 08387
IMGT
EMBL AC021593 AK090478 AK128327 AY057380 AY099358 AY099359 AY236500 BC028076 BC110296
GenPept AAI10297 AAL25837 AAM44454 AAM44455 AAP69878 BAC03459 BAG54660

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca