InnateDB Protein
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IDBP-764796.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GPS1
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Protein Name
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Synonyms
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COPS1; CSN1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000462265
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InnateDB Gene
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IDBG-73152 (GPS1)
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Protein Structure
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Function |
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. {ECO:0000269PubMed:11285227, ECO:0000269PubMed:11337588, ECO:0000269PubMed:12628923, ECO:0000269PubMed:12732143, ECO:0000269PubMed:9535219}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:9535219}. Nucleus {ECO:0000269PubMed:9535219}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:8943324}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated |
Total |
81
[view]
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Protein-Protein |
81
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000717
Proteasome component (PCI) domain
IPR019585
26S proteasome, regulatory subunit Rpn7
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PFAM |
PF01399
PF10602
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PRINTS |
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PIRSF |
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SMART |
SM00088
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TIGRFAMs |
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Modification |
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SwissProt |
Q13098
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PhosphoSite |
PhosphoSite-Q13098
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TrEMBL |
J3QS88
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UniProt Splice Variant |
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Entrez Gene |
2873
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UniGene |
Hs.268530
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RefSeq |
XP_005256417
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HUGO |
HGNC:4549
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OMIM |
601934
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CCDS |
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HPRD |
15991
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IMGT |
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EMBL |
AC135056
AK093283
BC000155
BC064503
BT009834
CH471099
U20285
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GenPept |
AAC50906
AAH00155
AAH64503
AAP88836
BAC04120
EAW89742
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