InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ERCC2

Summary

InnateDB Protein

IDBP-765995.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERCC2

Protein Name

Synonyms

COFS2; EM9; TFIIH; TTD; XPD;

Species

Homo sapiens

Ensembl Protein

ENSP00000465207

InnateDB Gene

IDBG-57385 (ERCC2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.

Experimentally validated
Total	43 [view]
Protein-Protein	42 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005524	ATP binding
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Biological Process

GO:0032508

DNA duplex unwinding

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR006554 Helicase-like, DEXD box c2 type
IPR010614 DEAD2
IPR014013 Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF06733

PRINTS

PIRSF

SMART

SM00488

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite