InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SUPV3L1

Summary

InnateDB Protein

IDBP-76608.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SUPV3L1

Protein Name

suppressor of var1, 3-like 1 (S. cerevisiae)

Synonyms

SUV3;

Species

Homo sapiens

Ensembl Protein

ENSP00000352678

InnateDB Gene

IDBG-76606 (SUPV3L1)

Protein Structure

UniProt Annotation

Function

Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. {ECO:0000269PubMed:12466530, ECO:0000269PubMed:15096047, ECO:0000269PubMed:17352692, ECO:0000269PubMed:17961633, ECO:0000269PubMed:18678873, ECO:0000269PubMed:19509288, ECO:0000269PubMed:19864255}.

Subcellular Localization

Nucleus. Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid.

Disease Associations

Tissue Specificity

Broadly expressed. {ECO:0000269PubMed:10453991}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0004004	ATP-dependent RNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0034458	3'-5' RNA helicase activity
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000958	mitochondrial mRNA catabolic process
GO:0000962	positive regulation of mitochondrial RNA catabolic process
GO:0000965	mitochondrial RNA 3'-end processing
GO:0006200	ATP catabolic process
GO:0006310	DNA recombination
GO:0006401	RNA catabolic process
GO:0030307	positive regulation of cell growth
GO:0032508	DNA duplex unwinding
GO:0035945	mitochondrial ncRNA surveillance
GO:0035946	mitochondrial mRNA surveillance
GO:0043066	negative regulation of apoptotic process
GO:0070584	mitochondrion morphogenesis
GO:0070827	chromatin maintenance
GO:2000827	mitochondrial RNA surveillance

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0042645	mitochondrial nucleoid
GO:0045025	mitochondrial degradosome

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR022192 Mitochondrial degradasome RNA helicase subunit, C-terminal domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF12513

PRINTS

PIRSF

SMART

SM00490

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8IYB8