InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TOMM22

Summary

InnateDB Protein

IDBP-7684.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TOMM22

Protein Name

translocase of outer mitochondrial membrane 22 homolog (yeast)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000216034

InnateDB Gene

IDBG-7682 (TOMM22)

Protein Structure

UniProt Annotation

Function

Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore. {ECO:0000269PubMed:10982837}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	27 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008320	protein transmembrane transporter activity

Biological Process

GO:0006626	protein targeting to mitochondrion
GO:0006886	intracellular protein transport
GO:0044267	cellular protein metabolic process
GO:0045040	protein import into mitochondrial outer membrane

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005742	mitochondrial outer membrane translocase complex
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0016021	integral component of membrane