InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RALBP1

Summary

InnateDB Protein

IDBP-777.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RALBP1

Protein Name

ralA binding protein 1

Synonyms

RIP1; RLIP1; RLIP76;

Species

Homo sapiens

Ensembl Protein

ENSP00000019317

InnateDB Gene

IDBG-775 (RALBP1)

Protein Structure

UniProt Annotation

Function

Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin. {ECO:0000269PubMed:11437348, ECO:0000269PubMed:12775724, ECO:0000269PubMed:7673236}.

Subcellular Localization

Membrane {ECO:0000269PubMed:11437348}; Peripheral membrane protein {ECO:0000269PubMed:11437348}.

Disease Associations

Tissue Specificity

Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes. {ECO:0000269PubMed:11437348}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0016887	ATPase activity
GO:0017160	Ral GTPase binding
GO:0030675	Rac GTPase activator activity
GO:0043492	ATPase activity, coupled to movement of substances
GO:0048365	Rac GTPase binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0006935	chemotaxis
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0032855	positive regulation of Rac GTPase activity
GO:0043087	regulation of GTPase activity
GO:0043089	positive regulation of Cdc42 GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction