InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PGAP1

Summary

InnateDB Protein

IDBP-77854.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGAP1

Protein Name

post-GPI attachment to proteins 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000346809

InnateDB Gene

IDBG-77852 (PGAP1)

Protein Structure

UniProt Annotation

Function

Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004518	nuclease activity
GO:0016788	hydrolase activity, acting on ester bonds
GO:0042578	phosphoric ester hydrolase activity

Biological Process

GO:0006501	C-terminal protein lipidation
GO:0006505	GPI anchor metabolic process
GO:0006506	GPI anchor biosynthetic process
GO:0006886	intracellular protein transport
GO:0007605	sensory perception of sound
GO:0009880	embryonic pattern specification
GO:0009948	anterior/posterior axis specification
GO:0015798	myo-inositol transport
GO:0016255	attachment of GPI anchor to protein
GO:0021871	forebrain regionalization
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0060322	head development
GO:0090305	nucleic acid phosphodiester bond hydrolysis